Table of Contents
What is Inoh Disease?
The National Institute of Ophthalmology (INO) of the Ministry of Health (MINSA) attended during the month February of this year 35 cases of patients with conjunctivitis, while in the same month of 2007, 457 patients with this disease were registered, which represents a decrease of 92 per cent of these pictures.
This situation shows that the population is learning to prevent conjunctivitis and knowing when to go to an ophthalmological consultation, as a result of the prevention campaigns developed by the institution during the summer season,” said Rd. César Mendoza Barba, deputy director of the INO.
He clarified that the decrease in this ocular pathology had sustain in recent years, since 1998 when there was an intense outbreak of conjunctivitis that demanded the attention of 1,400 cases in February, the month of the highest peak in temperature in the country.
OH, duration or pathways are created using the INOH Client Tool by the INOH curators with a biological background. The INOH Client Tool has a strict error check function to minimize the chance of mistakes. And to ensure consistency across different curators, our pathway data is well-annotated by the INOH ontology terms.
What is Inoh?
Inch Ontology Viewer
OH, Ontology allows users to browse and search ontology by names, synonyms, and IDs of INOH, Union, KEGG, and GO (Figure 3). By clicking the search result, a new window appears in which the user can see the value of each attribute and where the term is located in the ontology hierarchy. By clicking the parent or child node of graph representation below the fact, another new window shows that node in the centre. Users can access the INOH pathway data through INOH Ontology Vien. By clicking the icon gerontology term, the INOH Client under Java Web Start starts and displays pathway data annotated with the selected ontology term.
OH, Client Tool for Pathway Navigation
OH, pathway data can query and represented graphically through the INOH Client tool, a pathway navigation/editor tool for editing and searching pathways in the INOH database, and provides an automatic layout function of compound treatment graph pathways. The INOH Clients were downloadable from our website. A user can query the Noah database for paths and pathway objects by specifying molecule names, biological process names, Orin OH object IDs (IDs of Union, GO, and any other databases are not acceptable) (Keyword or ID Search) (Figure 4 ). The participant match of the result list means that the child object on the compound graph contains the keyword. For example, the keyword ‘TGF’ results in 8 Diagram [e.g., TGF-b signalling (through TAK1)], 60 Events (e.g., Binding of TGF receptor complex and R-Sad), 330Material (e.g., TGF-b receptor I) hits.
Similarity Search in Inoh Disease with Ontological Support
We developed a prototype web tool that accepts a graph query, whose nodes and edges are proteins and their relations. If respectively, or ‘Event’ and their connections, respectively, and searches. The pathway/network data for similar subgraphs on the INOH database (Similarity Search). The sub graphs matching the query order by their similarity scores. Each sub-graph similarity score (evaluation value) calculate from the semantic distance. OH, ontology terms and insertion and deletion nodes and edges in a graph. The results may include unexpect pathways. such as pathways with similar functional molecules and partially. It conserves pathways between different species, due to cosmetic searching up and down the Noah ontology’s hierarchy. These pathways will not obtain the exact matching to the ontology terms keywords.
OH APIs
The Inoh Disease Provides Simple Object Access Protocol (SOAP)
Web service Application Programming Interfaces (APIs). A user who wants to programmatically access INOH pathway data (INOH XML format) can do a keyword and pathway retrieval search using these APIs. Users can access the services through programming languages such as Perl, Python, Ruby, and Java. For example, a user can do a keyword Disease search that specifies the node type and property, e.g., node type: ‘event Compound,’ property: ‘Organism,’ keyword: ‘Drosophila.’ For example. ID’s pathways, e.g., ‘II0000057’ is the diagram (Notch signalling pathway), can display on the graphical user interface (INOH Client tool)
Conclusion
The INOH database is a highly structured, manually curated database of signal transduction pathways. And also, The similarity search uses the combination of a graph and hierarchical ontologies. Is a unique feature that other databases or ontologies have never achieved. We demonstrated the prediction of pathways related to a user-defined protein network. As users can edit and save their paths. And also, The INOH Client tool now serves both as an editor tool and query tool. We have to separate these to avoid confusion. Furthermore, downloading and installing the INOH Client tool is not the best for users. We will update our web interface in the future to allow users to easily access it. And also, All pathways and search functions instead of the INOH Client.